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ORCID: Affiliation: 14 International Joint Research Center on Purinergic Signalling, School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China 15 Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China These authors contributed equally to this work

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G2000 treatment significantly decreased -hydroxybutyrate than the HFD group, which suggests that Godex acted to reduce hepatic glucose production, primarily by suppressing gluconeogenesis and improved glucose tolerance through the marked reduction of the hepatic lipid contents in HFD mice